The police front counter in Teddington is among 37 police stations facing imminent closure as over half are to be scrapped.
The closures leave just one 24-hour police station open in each borough.
Khan explained that police offers would continue to patrol areas with a high crime rate in order to respond quickly to emergencies.
Dedicated neighbourhood police will double by the end of this year and will will be based at new ward-level hubs closer to communities.
The Mayor said that the plans will save an £8millon which is equivalent to the cost of 140 police constables.
The Mayor of London, Sadiq Khan, said: “Keeping Londoners safe is my number-one priority, and supporting officers out on the beat in our communities is more important than keeping open buildings that are simply not used by the vast majority of the public, and where just eight per cent of crimes are reported.
“Nevertheless, I understand and share some of the very legitimate concerns of Londoners about these closures. That is why we held the widest possible consultation with public meetings in every London borough and we have listened very carefully to the feedback.”